Rhino-Orbito-Cerebral Mucormycosis in Transfusion Associated Graft-Versus-Host Disease Case Report

Transfusion-associated graft-versus-host disease (TA- GVHD) is in most cases refractory to immunosuppressive therapy and fatal because of severe bone marrow apla- sia. Mucormycosis is a rare invasive fungal infection, but it has clinical importance because of its often delayed di- agnosis and high mortality. Invasive mucomycosis is fre- quently associated with diabetes mellitus, neutropenia, severe immunodeficiencies following steroid therapy, organ transplantation, cytotoxic chemotherapy, and AIDS. We present a case of lethal rhino-orbito-cerebral mucormycosis after TA-GVHD in an initially healthy pa- tient.